Since 2020, the ISOLDA consortium has been collaborating to develop improved vaccines against viral infections for older adults. The collaboration has resulted in a number of peer-reviewed articles in academic journals. Over the coming months, we will share these articles in the News section of our website.
Following part 1, part 2, part 3, and part 4 of this blog series, the consortium is proud to present another nine academic publications related to project ISOLDA:
| # | Title | Authors | Journal | DOI and URL |
|---|---|---|---|---|
| 25 | Comparison of two antibody screening systems for SARS-CoV-2 antibody detection in recovered and vaccinated subjects - test performance and possible indicators for immunity | Rebecca Jonczyk, Nils Stanislawski, Lisa K Seiler, Somayeh Ahani, Arne Bueltemeier, Frank Stahl, Sascha Beutel, Holger Blume, Corinna Hauß, Anette Melk, Mira Paulsen, Meike Stiesch, Andreas Winkel, Philipp-Cornelius Pott, Giulietta Saletti, Mariana González-Hernández, Franziska Karola Kaiser, Guus F Rimmelzwaan, Albert D M E Osterhaus, Cornelia Blume | J Clin Virol | 10.1016/j.isci.2023.106309 View here |
| 26 | Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults | Miguel Ángel Palacios-Pedrero, Janina M. Jansen, Cornelia Blume, Nils Stanislawski, Rebecca Jonczyk, Antonia Molle, Mariana Gonzalez Hernandez, Franziska K. Kaiser, Klaus Jung, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan & Giulietta Saletti | Nature Aging | 10.1038/s43587-022-00292-y View here |
| 27 | SARS-CoV-2 ORF8 accessory protein is a virulence factor | M Bello-Perez, J Hurtado-Tamayo, A Z Mykytyn, M M Lamers, R Requena-Platek, D Schipper, D Muñoz-Santos, J Ripoll-Gómez, A Esteban, P J Sánchez-Cordón, L Enjuanes, B L Haagmans, I Sola | mBio | 10.1128/mbio.00451-23 View here |
| 28 | SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice | Yousef M. Alhammad, Srivatsan Parthasarathy, Roshan Ghimire, Anthony R. Fehr | PNAS | 10.1073/pnas.2302083120 View here |
| 29 | FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants | Robert Meineke, Sonja Stelz, Maximilian Busch, Christopher Werlein, Mark Kühnel, Danny Jonigk, Guus F Rimmelzwaan, Husni Elbahesh | iScience | 10.1016/j.isci.2023.106309 View here |
| 30 | Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology | Lucía Morales, Juan Carlos Oliveros, Luis Enjuanes, Isabel Sola | mBio | 10.1128/mbio.03135-21 View here |
| 31 | CBL E3 ubiquitin ligases are key inhibitory regulators in PD-1/LAG-3 co-signaling in human cancers, targeted through bispecific co-blockade | L. Chocarro, L. Fernández-Rubio, M.J. Garcia Granda, E. Blanco Palmeiro, A.I. Bocanegra Gondan, M. Echaide, M. Garnica, M. Zuazo, C. Johnston, C.J. Edwards, J. Leggs, A. Pierce, H. Arasanz, R. Vera, K. Ausin, E. Santamaría, J. Fernández-Irigoyen, G. Kochan, D. Escors | Annals of Oncology | 10.1016/j.annonc.2023.09.1518 View here |
| 32 | Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions | Mercedes Lachén-Montes, Naroa Mendizuri, Karina Ausín, Miriam Echaide, Ester Blanco, Luisa Chocarro, María de Toro, David Escors, Joaquín Fernández-Irigoyen, Grazyna Kochan, Enrique Santamaría | Frontiers in Immunology | 10.3389/fimmu.2022.866564 View here |
| 33 | Clinical landscape of LAG-3-targeted therapy | L Chocarro, E Blanco, H Arasanz, L Fernández-Rubio, A Bocanegra, M Echaide, M Garnica, P Ramos, G Fernández-Hinojal , R Vera, G Kochan, D Escors | Immuno-oncology Technology | 10.1016/j.iotech.2022.100079 View here |
| 34 | 40P Identification of a PD-1/LAG-3 co-expression profile in human tumor-infiltrating T cells uncovers a T cell dysfunctionality genetic regulated programme | L. Chocarro, E. Blanco, H. Arasanz, L. Fernández-Rubio, A.I. Bocanegra, M. Echaide, M. Garnica, P. Ramos, S. Piñeiro-Hermida, M.J. García-Granda, R. Vera, E. Santamaría, J. Fernández-Irigoyen, G. Kochan, D. Escors | Annals of Oncology | 10.1016/j.annonc.2022.07.067 View here |
| 35 | Leading Edge: Intratumor Delivery of Monoclonal Antibodies for the Treatment of Solid Tumors | Ester Blanco, Luisa Chocarro, Leticia Fernández-Rubio, Ana Bocanegra, Hugo Arasanz, Miriam Echaide, Maider Garnica, Sergio Piñeiro-Hermida, Grazyna Kochan, David Escors | International Journal of Molecular Sciences | 10.3390/ijms24032676 View here |
| 36 | Inhibition of Host Kinase Activity: Effects on Influenza A Virus Infection and Host Cell Signaling | Robert Meineke | N/A (Thesis/Dissertation) | View here |
| 37 | Cutting-Edge CAR Engineering: Beyond T Cells | Luisa Chocarro, Ester Blanco, Leticia Fernández-Rubio, Hugo Arasanz, Ana Bocanegra, Miriam Echaide, Maider Garnica, Pablo Ramos, Sergio Piñeiro-Hermida, Ruth Vera, Grazyna Kochan, David Escors | Biomedicines | 10.3390/biomedicines10123035 View here |
| 38 | 55P Clinical landscape of LAG-3-targeted therapy | L. Chocarro, E. Blanco, H. Arasanz, A. Bocanegra, L. Fernández-Rubio, M. Echaide, M. Garnica, P. Ramos, G. Fernández-Hinojal, R. Vera, G. Kochan, D. Escors | Annals of Oncology | 10.1016/j.annonc.2021.08.2051 View here |
| 39 | Relevancia del motivo PBM de la proteína E en la replicación y virulencia de los coronavirus. | José Manuel Honrubia Belenguer | N/A (Thesis/Dissertation) | View here |
| 40 | Human coronavirus-host interactions: pathogenesis and antiviral response | Li Wang | N/A (Thesis/Dissertation) | View here |
| 41 | Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase | Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola, Eric J. Snijder & Marjolein Kikkert | Nature Communications | 10.1038/s41467-023-36754-z View here |
| 42 | Contribution to pathogenesis of accessory proteins of deadly human coronaviruses | Jesus Hurtado-Tamayo, Ricardo Requena-Platek, Luis Enjuanes, Melissa Bello-Perez, Isabel Sola | Frontiers in Cellular and Infection Microbiology | 10.3389/fcimb.2023.1166839 View here |
| 43 | Cell type dependent stability and virulence of a recombinant SARS-CoV-2, and engineering of a propagation deficient RNA replicon to analyze virus RNA synthesis | Li Wang, María Guzman, Diego Muñoz-Santos, Jose Manuel Honrubia, Jorge Ripoll-Gomez, Rafael Delgado, Isabel Sola, Luis Enjuanes, Sonia Zuñiga | Frontiers in Cellular and Infection Microbiology | 10.3389/fcimb.2023.1268227 View here |
| 44 | SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice. | Yousef M Alhammad, Srivatsan Parthasarathy, Roshan Ghimire, Joseph J O'Connor, Catherine M Kerr, Jessica J Pfannenstiel, Debarati Chanda, Caden A Miller, Robert L Unckless, Sonia Zuniga, Luis Enjuanes, Sunil More, Rudragouda Channappanavar, Anthony R Fehr | bioRxiv | 10.1101/2023.04.06.535927 View here |
| 45 | SARS-CoV-2 ORF8 accessory protein is a virulence factor. | M Bello-Perez, J Hurtado-Tamayo, A Z Mykytyn, M M Lamers, R Requena-Platek, D Schipper, D Muñoz-Santos, J Ripoll-Gómez, A Esteban, P J Sánchez-Cordón, L Enjuanes, B L Haagmans, I Sola | mBio | 10.1128/mbio.00451-23 View here |
| 46 | mRNA Vaccines against SARS-CoV-2: Advantages and Caveats. | Miriam Echaide, Luisa Chocarro de Erauso, Ana Bocanegra, Ester Blanco, Grazyna Kochan, David Escors | International Journal of Molecular Sciences | 10.3390/ijms24065944 View here |
| 47 | Oleuropein enhances anti-SARS-CoV-2 T-cell immunity in young and older vaccinees | N/A | N/A (In preparation) | N/A |
| 48 | PD-1/LAG-3 co-signaling profiling uncovers CBL ubiquitin ligases as key immunotherapy targets | Luisa Chocarro, Ester Blanco, Leticia Fernandez-Rubio, Maider Garnica, Miren Zuazo, Maria Jesus Garcia, Ana Bocanegra, Miriam Echaide, Colette Johnston, Carolyn J Edwards, James Legg, Andrew J Pierce, Hugo Arasanz, Gonzalo Fernandez-Hinojal, Ruth Vera, Karina Ausin, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Grazyna Kochan, David Escors | EMBO Molecular Medicine | doi.org/10.1038/s44321-024-00098-y View here |
| 49 | Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity | Amare Aregay,Jan Slunečko, Petra Bogovic, Miša Korva, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Imke Steffen, Franc Strle, Tatjana Avšič-Županc, Albert D.M.E. Osterhaus, Guus F. Rimmelzwaan | Emerging Microbes & Infections | 10.1080/22221751.2024.2317909 View here |
| 50 | Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins | Amare Aregay, Jan Slunečko, Miša Korva, Petra Bogovic, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Tatjana Avšič-Županc, Imke Steffen, Franc Strle, Albert D. M. E. Osterhaus & Guus F. Rimmelzwaan | npj Vaccines | 10.1038/s41541-024-00936-7 View here |
| 51 | Interaction between SARS-CoV PBM and Cellular PDZ Domains Leading to Virus Virulence | Jose M Honrubia, Jose R Valverde, Diego Muñoz-Santos, Jorge Ripoll-Gómez, Nuria de la Blanca, Jorge Izquierdo, Marta Villarejo-Torres, Ana Marchena-Pasero, María Rueda-Huélamo, Ivan Nombela, Mercedes Ruiz-Yuste, Sonia Zuñiga, Isabel Sola, Luis Enjuanes | Viruses | 10.3390/v16081214 View here |
| 52 | Fractalkine in Health and Disease | Claudia Rodriguez, Luisa Chocarro, Miriam Echaide, Karina Ausin, David Escors, Grazyna Kochan | International Journal of Molecular Sciences | 10.3390/ijms25158007 View here |
| 53 | Role of Sex and Age in Fatal Outcomes of COVID-19: Women and Older Centenarians Are More Resilient | Calogero Caruso, Gabriella Marcon, Giulia Accardi, Anna Aiello, Anna Calabrò, Mattia Emanuela Ligotti, Mauro Tettamanti, Claudio Franceschi, Giuseppina Candore | International Journal of Molecular Sciences | 10.3390/ijms24032638 View here |
| 54 | Centenarians born before 1919 are resistant to COVID-19 | Calogero Caruso, Giulia Accardi, Anna Aiello, Anna Calabrò, Mattia Emanuela Ligotti & Giuseppina Candore | Aging Clinical and Experimental Research | 10.1007/s40520-022-02287-6 View here |
| 55 | Sicilian semi- and supercentenarians: identification of age-related T cell immunophenotype to define longevity trait | Mattia Emanuela Ligotti, Giulia Accardi, Anna Aiello, Stefano Aprile, Anna Calabrò, Rosalia Caldarella, Calogero Caruso, Marcello Ciaccio, Anna Maria Corsale, Francesco Dieli, Marta Di Simone, Giovanni Maurizio Giammanco, Chiara Mascarella, Arne N Akbar, Serena Meraviglia, Giuseppina Candore | Clinical and Experimental Immunology | 10.1093/cei/uxad074 View here |
| 56 | Sex and gender affect immune aging | Anna Calabrò, Giulia Accardi, Anna Aiello, Calogero Caruso, Giuseppina Candore | Frontiers in Aging | 10.3389/fragi.2023.1272118 View here |
| 57 | Sicilian semi- and supercentenarians: age-related NK cell immunophenotype and longevity trait definition. | Mattia E Ligotti, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Anna M Corsale, Francesco Dieli, Marta Di Simone, Serena Meraviglia, Giuseppina Candore | Translational Medicine @ UniSa | 10.37825/2239-9747.1041 View here |
| 58 | The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity | Giulia Accardi, Anna Aiello, Stefano Aprile, Anna Calabrò, Rosalia Caldarella, Calogero Caruso, Marcello Ciaccio, Francesco Dieli, Mattia Emanuela Ligotti, Serena Meraviglia, Giuseppina Candore | Journal of Clinical Medicine | 10.3390/jcm12247591 View here |
| 59 | Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19 | Claudia Maria Trombetta, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Mattia Emanuela Ligotti, Serena Marchi, Emanuele Montomoli, Martin Mayora Neto, Nigel Temperton & Giuseppina Candore | Immunity & Ageing | 10.1186/s12979-024-00450-3 View here |
| 60 | Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies | Anna Calabrò, Giulia Accardi, Anna Aiello, Calogero Caruso, Damiano Galimberti, Giuseppina Candore | International Journal of Molecular Sciences | 10.3390/ijms25031792 View here |
| 61 | Improving flu-vaccination response for older adults. Preliminary results from ISOLDA study on in vitro model | N/A | N/A (Submitted) | N/A |
